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An independent review of two long-acting antibiotics used in Ireland finds they’re a safe and effective treatment for tuberculosis
One of the long-acting antibiotics prescribed to some sufferers of tuberculosis in Ireland is not linked to increased risk of tuberculosis, according to a review carried out by the Public Health Service (PHS).
The research highlights risks of antibiotic use for tuberculosis but also highlights the potential for benefit.
Methicillin-resistant tuberculosis is a disease that kills around 800 people worldwide each year. It is caused by strains of tuberculosis that can adapt in a way that makes them resistant to some types of antibiotic.
While it is very rare, there is an increased risk of developing the disease if individuals are taking long-acting beta-lactams (also known as aminoglycosides) because the bacteria evolve resistance to the drug given to them to treat infections.
In a review led by Marie-Louise Murphy, lead consultant in tuberculosis medicine in PHS, the review found the two antibiotics commonly prescribed to patients with the disease are neither linked to a risk of developing tuberculosis or to a reduction in the rate at which patients develop the disease.
Although there has been some suggestion that aminoglycosides may have an increased risk of causing a problem with the body’s immune system and lead to an allergic reaction, this does not appear to be substantiated in this review.
The review found the majority of patients, who were in Ireland for six months or longer in most cases, were correctly given the aminoglycosides. Around two-thirds of those in the study took them.
While the risk of developing tuberculosis is low, the review notes that there is a possibility that, if a patient comes down with the disease, his or her immune system may react to them and, in turn, worsen symptoms. There
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